GPL-SNP1000: DNA SEQUENCING PROFILE

GENERAL

This test is the most comprehensive test for alterations in the genetic code in the pathways that are most important for integrative medicine. This test looks at nine core groups of genes which are crucial for many different biological pathways. 

Here are the pathways that GPL-SNP1000 assesses:

  • DNA Methylation

  • Oxalate Metabolism

  • Mental Disorders / SAM-E/B12 Metabolism

  • Gluten Opioid Peptide Homeostasis

  • Autism Spectrum Genes

  • P450s (cyps)

  • Cholesterol Deficiency

  • Acetaminophen Toxification/Detoxification

  • Transporters

GPL-SNP1000 will help you understand how these nine genetic pathways are performing in you. These pathways were selected because of their importance in overall health. This test will help you understand your risks for developing different disorders and guide you to the best treatment for you. The GPL-SNP1000 in combination with the Organic Acids Test is a powerhouse of diagnostics (both genetic and metabolic) for you, unlike anything else available.

PATHWAYS

DNA Methylation
The methylation pathway is the complex process by which carbons are added onto folic acid and redistributed onto other compounds in the body. This pathway is responsible for the formation of methionine and thymidylate monophosphate (dTMP). These compounds play critical roles in nucleotide synthesis, neurotransmitter function, detoxification, and numerous other processes. The recycling of carbons for use in the methylation pathway is critical for cellular function. These enzymes are coded for on the end of the 21st chromosome, making them more susceptible to mutations.

Mental Disorders / SAM-E/B12 Metabolism
The mental health panel identifies mutations to many of the genes that influence mental health. The enzymes in this panel either degrade or modify many different types of neurotransmitters. Mutations to these genes can cause an increased risk of developing depression, schizophrenia, anxiety, and bipolar disorder

 

Oxalate Metabolism
Everyone obtains oxalates from three sources: liver cells (endogenously), yeast species (exogenously), and food (also exogenously). The degree to which an individual is predisposed to having adverse consequences from high levels of oxalate is influenced by their ability to metabolize oxalates. Deposition of oxalates in critical tissues such as brain and blood vessels, and the oxidative damage caused by oxalate salts can lead to symptoms of pain, nephrolithaisis, and possibly neurological symptoms.

Gluten Opioid Peptide Homeostasis
The gluten sensitivity panel looks at a large portion of the genes that if mutated, could lead to gluten sensitivity. Mutation in any of these genes may indicate the need to limit or eliminate gluten from the diet. Gluten sensitivity can manifest in a variety of symptoms. Many patients with autism spectrum disorder report neurological benefits upon switching to a gluten-free diet.

 

Autism Spectrum Genes
Autism spectrum disorder (ASD) is a developmental disability that is characterized by unique cognitive and behavioral symptoms that vary in degrees of severity. Recently, there have been multiple studies that have identified a series of genetic mutations that are more commonly found in patients with ASD than found in the general population. If a patient has one of these mutations, it does not mean that he/she will develop ASD, but their risk for developing ASD may be higher than the general public.

 

P450s (cyps)
The cytochrome P450s are a family of monooxygenase enzymes that are expressed throughout the body, but are most prevalent in the liver. They detoxify exogenous chemicals (including medical drugs) and metabolize endogenous chemicals including hormones, neurotransmitters, cholesterol, and vitamins. Mutations to some of the P450s could alter the appropriate dosage for many medications and could have long-term health consequences.

 

Cholesterol Deficiency (synthesis/absorption/transport)
Cholesterol is a very important molecule for the body. It is used to produce crucial hormones, vitamins, secondary messengers, and bile acids. Low values are associated with increased violent behavior, suicide, depression, anxiety, bipolar disease, Parkinson’s disease, and increased mortality from cancer. Low cholesterol values are also associated with manganese deficiency, celiac disease, hyperthyroidism, liver disease, malabsorption, and malnutrition.

 

Acetaminophen Toxification/Detoxification
Acetaminophen (Paracetamol, Tylenol) is one of the most commonly used pain relievers. Proper metabolization of acetaminophen is critical to preventing toxicity and any resulting damage. Genetic mutations that cause an increase in the metabolite NAPQI or that limit the body’s ability to detoxify acetaminophen will make a person more susceptible to adverse effects from acetaminophen usage.

 

Transporters
Transport proteins are important for shuttling molecules across cellular membranes. Mutations to transporter genes impede the ability of cells to uptake vital nutrients and export toxic substances. There are numerous diseases associated with faulty transport including Alzheimer’s disease, coronary artery disease, aggressive behavior, and decreased drug efficacy.

TESTING FOR GPL-SNP1000

GPL-SNP testing can identify your patients’ predisposition to the following:

  • ADHD

  • Adverse Drug Reactions

  • Allergies

  • Anxiety

  • Arthritis

  • Autism Spectrum Disorders

  • Bipolar Disorder

  • Cancer

  • Depression

  • Heart Disease

  • Osteoporosis

  • Oxidative Stress

  • Schizophrenia

  • And More