From The National Cancer Institute
IV Vitamin C
Have any preclinical (laboratory or animal) studies been conducted using high-dose vitamin C?
Many laboratory studies have been done to find out how high-dose vitamin C may cause the death of cancer cells. The anticancer effect of vitamin C in different types of cancer cells involves a chemical reaction that makes hydrogen peroxide, which may kill cancer cells.
Laboratory studies have shown the following:
Combining high-dose vitamin C with certain types of chemotherapy may be more effective than chemotherapy alone:
Ascorbic acid with gemcitabine and epigallocatechin-3-gallate (EGCG) may be more effective in malignant mesothelioma cells.
However, not all laboratory studies combining vitamin C with anticancer therapies have shown benefit. Combining dehydroascorbic acid, a particular form of vitamin C, with chemotherapy made it less effective in killing some kinds of cancer cells.
Studies of high-dose vitamin C have been done in animal models (animals given a disease either the same as or like a disease in humans).
Some of the studies showed the vitamin C helped kill more cancer cells:
High-dose vitamin C blocked tumor growth in animal models of pancreatic, liver, prostate, sarcoma, and ovarian cancers and malignant mesothelioma.
High-dose vitamin C combined with chemotherapy in a mouse model of pancreatic cancer showed that the combination treatment shrank tumors more than chemotherapy treatment alone.
Another study showed that vitamin C made a type of light therapy more effective when used to treat mice injected with breast cancer cells.
A study in a mouse model of ovarian cancer showed that combining intravenous high-dose vitamin C with the anticancer drugs carboplatin and paclitaxel made them more effective in treating ovarian cancer.
However, other animal studies have shown that vitamin C interferes with the anticancer action of certain drugs, including the following:
Have any clinical trials (research studies with people) of high-dose intravenous (IV) vitamin C been conducted?
Several studies of high-dose vitamin C in patients with cancer have been done in recent years, including the following:
Studies of vitamin C alone
Intravenous (IV) vitamin C was studied in patients with breast cancer who were treated with adjuvant chemotherapy and radiation therapy. The study found that patients who received IV vitamin C had better quality of life and fewer side effects than those who did not.
A study of IV vitamin C and high doses of vitamin C taken by mouth was done in patients with cancer that could not be cured. Vitamin C was shown to be a safe and effective therapy to improve quality of life in these patients, including physical, mental, and emotional functions, symptoms of fatigue, nausea and vomiting, pain, and appetite loss.
Vitamin C has been shown to be safe when given to healthy volunteers and cancer patients at doses up to 1.5 g/kg, while screening out patients with certain risk factors who should avoid vitamin C. Studies have also shown that Vitamin C levels in the blood are higher when taken by IV than when taken by mouth, and last for more than 4 hours.
Studies of vitamin C combined with other drugs
Studies of vitamin C combined with other drugs have shown mixed results:
In a small study of 14 patients with advanced pancreatic cancer, IV vitamin C was given along with chemotherapy and treatment with a targeted therapy. Patients had very few bad side effects from the vitamin C treatment. The nine patients who completed the treatment had stable disease as shown by imaging studies.
In another small study of 9 patients with advanced pancreatic cancer, patients were given chemotherapy in treatment cycles of once per week for 3 weeks along with IV vitamin C twice per week for 4 weeks. These patients had disease that did not progress for a period of months. The combined treatment was well tolerated and no serious side effects were reported.
In a 2014 study of 27 patients with advanced ovarian cancer, treatment with chemotherapy alone was compared to chemotherapy along with IV vitamin C. Patients who received IV vitamin C along with chemotherapy had fewer serious side effects from the chemotherapy.
Patients with acute myeloid leukemia, refractory metastatic colorectal cancer, or metastatic melanoma treated with IV vitamin C combined with other drugs had serious side effects and the disease got worse.
More studies of combining high-dose IV vitamin C with other drugs are in progress.
Have any side effects or risks been reported from high-dose vitamin C?
Intravenous high-dose ascorbic acid has caused very few side effects in clinical trials. However, high-dose vitamin C may be harmful in patients with certain risk factors.
In patients with a history of kidney disorders, kidney failure has been reported after ascorbic acid treatment. Patients with a tendency to develop kidney stones should not be treated with high-dose vitamin C.
Case reports have shown that patients with an inherited disorder called G-6-PD deficiency should not be given high doses of vitamin C, due to the risk of hemolysis (a condition in which red blood cells are destroyed).
Since vitamin C may make iron more easily absorbed and used by the body, high doses of the vitamin are not recommended for patients with hemochromatosis (a condition in which the body takes up and stores more iron than it needs).
Have any drug interactions been reported from combining high-dose vitamin C with anticancer drugs?
A drug interaction is a change in the way a drug acts in the body when taken with certain other drugs. High-dose vitamin C, when combined with some anticancer drugs, may cause them to be less effective. So far, these effects have been seen only in some laboratory and animal studies. No clinical trials have been done to further research these drug interactions in humans.
Combining vitamin C with an anticancer drug called bortezomib has been studied in cell cultures and in animal models. Bortezomib is a targeted therapy that blocks several molecular pathways in a cell, causing cancer cells to die. Several studies showed that vitamin C given by mouth made bortezomib less effective, including in multiple myeloma cells. A study in mice transplanted with human prostate cancer cells, however, did not show that giving the mice different doses of vitamin C by mouth made bortezomib therapy less effective.
An oxidized form of vitamin C called dehydroascorbic acid has been studied in cell cultures and in animals with tumors. Several studies have found that high doses of dehydroascorbic acid can interfere with the anticancer effects of several chemotherapy drugs. Dehydroascorbic acid is found in only small amounts in dietary supplements and in fresh foods.
Is high-dose vitamin C approved by the U.S. Food and Drug Administration for use as a cancer treatment in the United States?
The U.S. Food and Drug Administration (FDA) has not approved the use of high-dose vitamin C as a treatment for cancer or any other medical condition
Other Studies on IV Vitamin C
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21. Ma Y, Drisko J, Polireddy K, Chen Q. Synergistic Effects of Ascorbate with Carboplatin against Human Ovarian Cancer In Vitro and In Vivo 8th Annual Conference of the Society for Integrative Oncology; November 9-12, 2011; Cleveland, Ohio2011.
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28. Chen P, Stone J, Sullivan G, Drisko JA, Chen Q. Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary parenteral glutathione in preclinical cancer models. Free radical biology & medicine. 2011;51(3):681-7. Epub 2011/06/16.
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